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RESEARCH PAPER
 
 

Change in airway inflammatory markers in Danish energy plant workers during a working week

Yuduo Zheng 1,  
Anne M Madsen 2,  
Simon Skov 3,  
 
1
Institute of Public Health, Section for Environment, Occupation and Health, University of Aarhus and the Danish Ramazzini Centre, Aalborg, Denmark
2
The National Research Centre for the Working Environment, Copenhagen Denmark
3
Department of Geosciences and Natural Resource Management, University of Copenhagen, Hinnerup, Denmark
Ann Agric Environ Med 2014;21(3):534–540
KEYWORDS:
ABSTRACT:
[b]Introduction.[/b] It is well known that exposure to organic dust can cause adverse respiratory effect. The pathogen-associated molecular patterns (PAMPS) in the organic dust, such as endotoxin from Gram-negative bacteria cell wall and fungal components, can trigger the release of cytokine (e.g. Interleukin 1β (IL-1β)) and chemokine (e.g. Interleukin 8 (IL-8)) from the immune cells in the airways. [b]Objective.[/b] To evaluate the potential inflammatory effects of organic dust exposure in energy plants in Denmark. [b]Materials and methods[/b]. Nasal lavage (NAL) and exhaled breath condensate (EBC) were sampled at Monday morning (referred to as before work) and again at Thursday afternoon (referred to as after work). NAL IL-8, EBC pH, IL-1β concentration were measured. Personal exposure to endotoxin and dust was calculated from time spent on different tasks and measured average work area exposures. [b]Results.[/b] Before work, workers from biofuel plants had a higher IL-1β and IL-8 concentration compared to conventional fuel plants (control group). Specifically, the IL-1β level of moderately and most exposed group, and IL-8 level of the least exposed group were higher compared to the control group. The changes of IL-1β, pH and IL-8 during a work week were not significant. Workers with rhinitis had a lower percentage change of IL-8 compared to healthy workers. [b]Conclusions[/b]. An increased level of EBC IL-1β in biofuel energy plant workers before work indicated a chronic or sub-chronic inflammation. The percentage change of IL-8 was lower in workers with rhinitis compared to healthy workers.
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eISSN:1898-2263
ISSN:1232-1966