RESEARCH PAPER
CHLAMYDOPHILA PSITTACI SEROPOSITIVITY AND SERUM LEVELS OF SOLUBLE INTERCELLULAR ADHESION MOLECULE-1 IN FARMERS
 
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1
Section of Occupational Health, Department of Social and Environmental Medicine, University of Messina, Italy
2
Department of Medical Veterinary Sciences, University of Messina, Italy
3
School and Division of Allergy and Clinical Immunology, Department of Human Pathology, University of Messina, Italy
4
Department of Pediatrics Science and Medical Surgery, University of Messina, Italy
CORRESPONDING AUTHOR
Concettina Fenga   

Dipartimento di Medicina Sociale del Territorio, Sezione di Medicina del Lavoro, Policlinico Universitario – Pad. H, Via Consolare Valeria – Gazzi, 95024 Messina (Italy).
 
Ann Agric Environ Med. 2008;15(2):277–280
 
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ABSTRACT
Chlamydophila infection is known as an occupational hazard to veterinarians, farmers, poultry workers. Serum levels of the soluble Intercellular Adhesion Molecule-1 (sICAM-1), is associated with C. seropositivity. Since no data about ICAM-1 levels and C. psittaci infection are known, the aim of this work was to assess if chronic persistent C. psittaci infection constantly stimulates the expression of sICAM-1, independent of the characteristic symptoms of ornithosis. C. psittaci seropositivity and serum concentrations of sICAM-1 were investigated in 30 farmers and 20 age-matched healthy public employees as controls. Increased serum sICAM-1 levels were found in the group of farmers exposed to infectious risk compared to controls, and the serum concentrations of sICAM-1 was significantly correlated with a high IgG titre against C. psittaci. It is therefore possible to suggest a sICAM-1 measurement for use as a tool to verify the development of C. psittaci chronic infection in an occupational setting.
eISSN:1898-2263
ISSN:1232-1966