ABO blood groups, Rhesus factor, and anaphylactic reactions due to Hymenoptera stings
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Department of Allergology, Clinical Immunology and Internal Diseases, L. Rydygier Collegium Medicum, Bydgoszcz, Poland
Ann Agric Environ Med 2017;24(3):428–430
Numerous publications indicate that the prevalence of some infectious, neoplastic and immunological diseases are associated with ABO blood groups.

The aim of this study was to verify whether ABO and Rh blood groups are associated with severe anaphylactic reactions after Hymenoptera stings.

Material and Methods:
A study was undertaken of 71,441 Caucasian subjects living in the same geographic area. The study group included 353 patients with diagnosed systemic anaphylaxis to Hymenoptera venom. Control group included 71,088 healthy blood donors. Frequencies of ABO and Rhesus groups in the study and control groups were compared using univariate and multivariate analyses.

No statistically significant interactions were observed between the ABO blood group and anaphylactic reactions to Hymenoptera.

Krzysztof Pałgan
Department of Allergology, Clinical Immunology and Internal Diseases, L. Rydygier Collegium Medicum, Bydgoszcz, Poland
1. Bilò BM, Bonifazi F. Epidemiology of insect-venom anaphylaxis. Curr Opin Allergy ClinImmunol. 2008; 8(4): 330–337.
2. Pałgan K. Postępowanie diagnostyczne i terapeutyczne u pacjentów uczulonych na jad owadów błonkoskrzydłych. Alergol. Pol. 2014: (1); 60–64.
3. Ruëff F, Vos B, Oude Elberink J, Bender A, Chatelain R, Dugas-Breit S, Horny HP, Küchenhoff H, Linhardt A, Mastnik S, Sotlar K, Stretz E, Vollrath R, Przybilla B, Flaig M. Predictors of clinical effectiveness of Hymenoptera venom immunotherapy. Clin Exp Allergy. 2014;44(5): 736–46.
4. Przybilla B, Ruëff F. Insect stings: clinical features and management. DtschArztebl Int. 2012;109 (13): 238–248.
5. Farhud D D, Yeganeh Z M. A brief history of human blood groups. Iran J Pub Health, 2013: 42(1); 1–6.
6. Franchini M, Bonfanti C. Evolutionary aspects of ABOblood group in humans. Clin Chim Acta. 2015; 444: 66–71.
7. Ring J, Messmer K. Incidence and severity of anaphylactoid reactions to colloid volume substitutes. Lancet1977; 1: 466–469.
8. Mohsenpour B, Hajibagheri K, Afrasiabian S, Ghaderi E, Ghasembegloo S. ABO blood groups and susceptibility to brucellosis. Jpn J Infect Dis. 2015; 68(2): 124–127.
9. Bedu-Addo G, Gai P P, Meese S, Eggelte T A, Thangaraj K, Mockenhaupt F P. Reduced prevalence of placental malaria in primiparae with blood group O. Malar J. 2014; 13: 289.
10. Aird I, Lee DR, Roberts IA. ABO blood groups and cancer of oesophagus, cancer of pancreas, and pituitary adenoma. Br Med J. 1960;1:1163–1166.
11. Franchini M, Lippi G. The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer. BMC Med. 2015 Jan 16;13:7. doi: 10.1186/s12916–014–0250-y.
12. Etemadi A, Kamangar F, Islami F, Poustchi H, Poursham A, Brennan P, Boffetta P, Malekzadeh R, Dawsey SM, Abnet CC, Emadi A. Mortality and cancer in relation to ABO blood group phenotypes in the Golestan Cohort Study. BMC Medicine. 2014. doi:10.1186/s12916–014–0237–8.
13. See comment in PubMed Commons belowFalsarella N, da Costa Ferreira A L, Nakashima F, de Cássia C, de Mattos B, de Mattos L C. Evidence of an association between the O blood group and allergic rhinitis. Rev Bras HematolHemoter. 2011; 33(6): 444–448.
14. Kauffmann F, Frette C, Pham QT, Nafissi S, Bertrand J P, Oriol R. Associations of blood group-related antigens to FEV1, wheezing, and asthma. American Journal of Respiratory and Critical Care Medicine1996; 153:1, 76–8.
15. Denborough MA, Downing HJ. Secretor status in asthma and hay fever. J Med Genet. 1968; 5(4): 302–305.
16. Bijanzadeh M, Ramachandra NB, Mahesh PA, Savitha MR, Manjunath BS, Jayaraj BS. Lack of association between asthma and ABO blood group. Lung. 2009; 187(6): 389–392.
17. Hamsten C, Tran TAT, Starkhammar M, Brauner A, Commins SP, Platts-Mills T AE, van Hage M. Red meat allergy in Sweden: Association with tick sensitization and B-negative blood groups. J Allergy Clin Immunol, 2013; 132(6), 1431–1434.