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<strong>The clinical and hormonal features of women with polycystic ovary syndrome living in rural areas and the city.</strong>

Adam Czyzyk 1,  
Sylwia Slawek 2,  
Department of Gynecological Endocrinology, Poznan University of Medical Sciences, Poznan, Poland
Students Scientific Society of the Department of Gynecological Endocrinology, Poznan University of Medical Sciences, Poznan, Poland
Division of Gynecological Surgery, Poznan University of Medical Sciences
[b]Abstract[/b] Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies among women in reproductive age but its pathology remains unknown. From the epidemiological studies it is known that endogenous, mainly genetic and exogenous, environmental factors are of importance. [b]Objectives[/b] The aim of the study was to compare the phenotype of women diagnosed with PCOS from urban and rural areas of Poland. According to our knowledge, it is first such a study. [b]Materials[/b] The retrospective study included 3877 PCOS patients: 2511 women living in cities and 1366 village inhabitants aged between 18 and 45 years. [b]Methods[/b] In each patient the clinical data, including medical history, body mass, height and hirsutism severity was obtained. We also analyzed the hormonal (follicle stimulating hormone, luteinizing hormone, prolactin, estradiol [E2], testosterone, – dehydroepiandrosterone sulphate [DHEAS], thyroid stimulating hormone, free thyroxin, insulin [INS], 17 hydroxyprogesterone, cortisol [CORT]) and metabolic (75g oral glucose tolerance test, Chol – total cholesterol, HDL-C – high density lipoprotein cholesterol, LDL-C low density lipoprotein cholesterol, TG – triglicerides) profile in each patient. [b]Results. [/b] PCOS women from urban areas had higher mean serum concentration of E2 in comparison to inhabitants of villages. The women from cities had lower mean level of DHEAS, CORT, and INS measured in the morning than rural residents. The insulin-resistance, using homeostasis model assessment, was more pronounced among women from villages. The prevalence of menstrual disorders was in general higher in PCOS women living in rural comparing to urban areas. [b]Conclusion[/b] The clinical and biochemical indices differ significantly between women diagnosed with PCOS living in cities and villages. In general, in Poland the PCOS phenotype is more severe in women living in rural areas. In this study we showed that different living conditions significantly affect the PCOS phenotype.